Assessment of vascular reactivity in two rat brain gliomas (C6 and RG2) by Blood Volume fraction MRI during CO2 challenge and correlation to mature vessels
نویسندگان
چکیده
Introduction: Microvascular maturation may vary across tumor types (1). Using histology, structural microvascular maturation is assessed by measuring the pericyte coverage index. Using MRI, functional microvascular maturation might be assessed by measuring vasoreactivity and blood volume fraction (BVf) under hypercapnic challenge. C6 and RG2 glioma, both permeable to Gd chelates, exhibit different molecular profiles (namely expressions of VEGF and Ang-2) (2). These two models might thus present differences in microvascular maturity. In this study, we compare both structural and functional microvascular maturation – assessed by histology and MRI – of these two orthotopic rat models.
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